METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Abstract Background N6-methyladenosine (m6A) modification of RNA influences fundamental aspects of RNA metabolism and m6A dysregulation is implicated in various human diseases. In this study, we explored the potential role of RNA m6A modification in the pathogenesis of Alzheimer disease (AD). Method...

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Bibliographic Details
Main Authors: Fanpeng Zhao, Ying Xu, Shichao Gao, Lixia Qin, Quillan Austria, Sandra L. Siedlak, Kinga Pajdzik, Qing Dai, Chuan He, Wenzhang Wang, James M. O’Donnell, Beisha Tang, Xiongwei Zhu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Neurodegeneration
Subjects:
RNA m6A modification
RNA methylation
METTL3
Alzheimer’s disease
Aberrant cell cycle events
Apoptosis
Online Access:https://doi.org/10.1186/s13024-021-00484-x

Internet

https://doi.org/10.1186/s13024-021-00484-x

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