ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

Abstract Mutations in Fused in Sarcoma/Translocated in Liposarcoma (FUS) cause familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive axonal degeneration mainly affecting motor neurons. Evidence from transgenic mouse models suggests mutant for...

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Main Authors: Reddy Ranjith K. Sama, Claudia Fallini, Rodolfo Gatto, Jeanne E. McKeon, Yuyu Song, Melissa S. Rotunno, Saul Penaranda, Izrail Abdurakhmanov, John E. Landers, Gerardo Morfini, Scott T. Brady, Daryl A. Bosco
Format: Article
Language:English
Published: Nature Portfolio 2017-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-00091-1

Internet

https://doi.org/10.1038/s41598-017-00091-1

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