Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn

Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn

Abstract We investigate a relatively underexplored component of the gut-immune axis by profiling the antibody response to gut phages using Phage Immunoprecipitation Sequencing (PhIP-Seq). To cover large antigenic spaces, we develop Dolphyn, a method that uses machine learning to select peptides from...

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Bibliographic Details
Main Authors: Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R. Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian Rewers, Randy Longman, June Round, Stephen Elledge, Ingo Ruczinski, Ben Langmead, H. Benjamin Larman
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45601-8

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https://doi.org/10.1038/s41467-024-45601-8

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