Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway

Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway

Abstract Background The aberrant formation of neutrophil extracellular traps (NETs) has been implicated in ulcerative colitis (UC), a chronic recurrent intestinal inflammation. Cyclosporine A (CsA) is now applied as rescue therapy for acute severe UC. In addition, it has been certained that CsA inhi...

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Bibliographic Details
Main Authors: Chenjing Xu, Ziping Ye, Wenyu Jiang, Shu Wang, Hongjie Zhang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Medicine
Subjects:
Ulcerative colitis
Cyclosporine A
Neutrophil extracellular traps
P53
Pentose phosphate pathway
Glucose-6-phosphate dehydrogenase
Online Access:https://doi.org/10.1186/s10020-023-00758-8

Internet

https://doi.org/10.1186/s10020-023-00758-8

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