CYP2C8 rs11572080 and CYP3A4 rs2740574 risk genotypes in paclitaxel-treated premenopausal breast cancer patients

CYP2C8 rs11572080 and CYP3A4 rs2740574 risk genotypes in paclitaxel-treated premenopausal breast cancer patients

Abstract Breast cancer (BC) is the most prevalent malignancy in women globally. At time of diagnosis, premenopausal BC is considered more aggressive and harder to treat than postmenopausal cases. Cytochrome P450 (CYP) enzymes are responsible for phase I of estrogen metabolism and thus, they are prom...

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Bibliographic Details
Main Authors: Hanaa R. M. Attia, Mahmoud M. Kamel, Dina F. Ayoub, Shereen H. Abd El-Aziz, Mai M. Abdel Wahed, Safa N. Abd El-Fattah, Mahmoud A. Ablel-Monem, Thanaa M. Rabah, Amany Helal, Mona Hamed Ibrahim
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Breast cancer
Cytochrome P450
Taxane
Menopausal status
Online Access:https://doi.org/10.1038/s41598-024-58104-9

Internet

https://doi.org/10.1038/s41598-024-58104-9

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