PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux

PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux

Pleckstrin Homology And RUN Domain Containing M2 (PLEKHM2) [delAG] mutation causes dilated cardiomyopathy with left ventricular non-compaction (DCM-LVNC), resulting in a premature death of PLEKHM2[delAG] individuals due to heart failure. PLEKHM2 is a factor involved in autophagy, a master regulator...

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Bibliographic Details
Main Authors: Hadas Ben-Zvi, Tatiana Rabinski, Rivka Ofir, Smadar Cohen, Gad D. Vatine
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
neurons
motor neurons
autophagy
PLEKHM2
DCM-LVNC
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/23/24/16092

Internet

https://www.mdpi.com/1422-0067/23/24/16092

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