TIMP3 overexpression in myeloid lineage alleviates pancreatic damage and confers resistance to the development of type 1 diabetes in the MLDS -induced model

TIMP3 overexpression in myeloid lineage alleviates pancreatic damage and confers resistance to the development of type 1 diabetes in the MLDS -induced model

IntroductionType 1 diabetes mellitus (T1DM) development involves a complex interplay of genetic, environmental, and immunological factors. By modulating the activity of proteases and receptors, the protein tissue inhibitor of metalloproteinase 3 (TIMP3) plays a role in limiting the expression and fu...

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Bibliographic Details
Main Authors: Viviana Casagrande, Stefano Menini, Chiara Internò, Giuseppe Pugliese, Massimo Federici, Rossella Menghini
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Endocrinology
Subjects:
pancreas
diabetes
TIMP3
myeloid cells
insulitis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1297847/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1297847/full

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