Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity.

Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity.

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3) and Breast cancer resistance protein (BCRP) are ef...

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Bibliographic Details
Main Authors: Juan Pablo Rigalli, Nadia Ciriaci, Agostina Arias, María Paula Ceballos, Silvina Stella Maris Villanueva, Marcelo Gabriel Luquita, Aldo Domingo Mottino, Carolina Inés Ghanem, Viviana Alicia Catania, María Laura Ruiz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119502

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https://doi.org/10.1371/journal.pone.0119502

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