Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?

Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?

The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines; however, the efficiency of the reaction could be aff...

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Bibliographic Details
Main Authors: Omar F. Luna, Johana Gomez, Constanza Cárdenas, Fernando Albericio, Sergio H. Marshall, Fanny Guzmán
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
N-α-deprotection reagent
piperazine
piperidine
4-methylpiperidine
solid-phase peptide synthesis
Online Access:http://www.mdpi.com/1420-3049/21/11/1542

Internet

http://www.mdpi.com/1420-3049/21/11/1542

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