Advances in the Study of Common and Rare <i>CFTR</i> Complex Alleles Using Intestinal Organoids

Advances in the Study of Common and Rare <i>CFTR</i> Complex Alleles Using Intestinal Organoids

Complex alleles (CAs) arise when two or more nucleotide variants are present on a single allele. CAs of the <i>CFTR</i> gene complicate the cystic fibrosis diagnosis process, classification of pathogenic variants, and determination of the clinical picture of the disease and increase the...

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Bibliographic Details
Main Authors: Maria Krasnova, Anna Efremova, Diana Mokrousova, Tatiana Bukharova, Nataliya Kashirskaya, Sergey Kutsev, Elena Kondratyeva, Dmitry Goldshtein
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Journal of Personalized Medicine
Subjects:
complex allele
cystic fibrosis
<i>CFTR</i>
intestinal organoid
targeted therapy
CFTR modulators
Online Access:https://www.mdpi.com/2075-4426/14/2/129

Internet

https://www.mdpi.com/2075-4426/14/2/129

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