Colorectal Cancer Bioengineered Microtissues as a Model to Replicate Tumor-ECM Crosstalk and Assess Drug Delivery Systems In Vitro

Colorectal Cancer Bioengineered Microtissues as a Model to Replicate Tumor-ECM Crosstalk and Assess Drug Delivery Systems In Vitro

Current 3D cancer models (in vitro) fail to reproduce complex cancer cell extracellular matrices (ECMs) and the interrelationships occurring (in vivo) in the tumor microenvironment (TME). Herein, we propose 3D in vitro colorectal cancer microtissues (3D CRC μTs), which reproduce the TME more faithfu...

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Bibliographic Details
Main Authors: Alessia La Rocca, Vincenza De Gregorio, Elena Lagreca, Raffaele Vecchione, Paolo Antonio Netti, Giorgia Imparato
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
tumor microenvironment (TME)
extracellular matrix (ECM)
cancer associated fibroblasts (CAF)
curcumin-loaded nanoemulsion (CT-NE-Curc)
5-Fluorouracil (5-FU)
Online Access:https://www.mdpi.com/1422-0067/24/6/5678

Internet

https://www.mdpi.com/1422-0067/24/6/5678

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