Chronic cough relief by allosteric modulation of P2X3 without taste disturbance

Chronic cough relief by allosteric modulation of P2X3 without taste disturbance

Abstract P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough (RCC) and other disorders. However, the present negative allosteric modulation of...

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Bibliographic Details
Main Authors: Chang-Run Guo, Zhong-Zhe Zhang, Xing Zhou, Meng-Yang Sun, Tian-Tian Li, Yun-Tao Lei, Yu-Hao Gao, Qing-Quan Li, Chen-Xi Yue, Yu Gao, Yi-Yu Lin, Cui-Yun Hao, Chang-Zhu Li, Peng Cao, Michael X. Zhu, Ming-Qiang Rong, Wen-Hui Wang, Ye Yu
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41495-0

Internet

https://doi.org/10.1038/s41467-023-41495-0

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