405 Role of Glycans in Cancer Associated Fibroblast-Derived Exosome Immunoregulation

OBJECTIVES/GOALS: To identify the role of sialoglycans in the mechanisms underlying cancer-associated fibroblast-derived exosomes (CAFEX) immuno-regulatory properties. The central hypothesis is that CAFEX manipulates the immune response to allow immunoevasion and glycomic approaches can identify the...

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Bibliographic Details
Main Authors: Johnathon D. Anderson, Jan Nolta, D. Gregory Farwell, Andrew Birkland, Judy Van de Water, Kermit Carraway, Carlito Lebrilla
Format: Article
Language:English
Published: Cambridge University Press 2022-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866122002333/type/journal_article