HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling

HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling

Abstract Bone remodeling is a continuous process between bone-forming osteoblasts and bone-resorbing osteoclasts, with any imbalance resulting in metabolic bone disease, including osteopenia. The HERC1 gene encodes an E3 ubiquitin ligase that affects cellular processes by regulating the ubiquitinati...

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Bibliographic Details
Main Authors: Leonardo Pedrazza, Arturo Martinez-Martinez, Cristina Sánchez-de-Diego, José Antonio Valer, Carolina Pimenta-Lopes, Joan Sala-Gaston, Michal Szpak, Chris Tyler-Smith, Francesc Ventura, Jose Luis Rosa
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05549-x

Internet

https://doi.org/10.1038/s41419-023-05549-x

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