Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis

Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis

Abstract Background Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of the joints, leading to bone erosion and joint dysfunction. Despite the recent successes of disease-modifying anti-rheumatic drugs (DMARDs), there is still clinical need for understan...

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Bibliographic Details
Main Authors: Susan MacLauchlan, Maria A. Zuriaga, José J. Fuster, Carla M. Cuda, Jennifer Jonason, Fernanda Behzadi, Jennifer Parker Duffen, G. Kenneth Haines, Tamar Aprahamian, Harris Perlman, Kenneth Walsh
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Wnt5a
Inflammation
Osteoclast fusion
Online Access:http://link.springer.com/article/10.1186/s13075-017-1375-0

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http://link.springer.com/article/10.1186/s13075-017-1375-0

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