The Influence of NAT2 Genotypes on Isoniazid Plasma Concentration of Pulmonary Tuberculosis Patients in Southern Thailand

The Influence of NAT2 Genotypes on Isoniazid Plasma Concentration of Pulmonary Tuberculosis Patients in Southern Thailand

Background Isoniazid (INH) is metabolized by polymorphic N-acetyltransferase 2 (NAT2) enzyme, which noticeably alters INH plasma concentration. We aimed to determine the distribution of NAT2 genotype in Thai tuberculosis (TB) patients and correlate their genotype with plasma INH concentrations. Meth...

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Bibliographic Details
Main Authors: Usanee Ungcharoen, Hutcha Sriplung, Surakameth Mahasirimongkol, Saranyou Chusri, Nuanjun Wichukchinda, Phongpan Mokmued, Sukanya Wattanapokayakit, Virasakdi Chongsuvivatwong
Format: Article
Language:English
Published: The Korean Academy of Tuberculosis and Respiratory Diseases 2020-12-01
Series:Tuberculosis and Respiratory Diseases
Subjects:
isoniazid
genotype
n-acetyltransferase 2
plasma concentration
tuberculosis
Online Access:http://www.e-trd.org/upload/pdf/trd-2020-0068.pdf

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