Different Strategies for Reducing Intestinal Background Radioactivity Associated with Imaging HSV1- Expression Using Established Radionucleoside Probes

Different Strategies for Reducing Intestinal Background Radioactivity Associated with Imaging HSV1- Expression Using Established Radionucleoside Probes

One limitation of HSV1- tk reporter positron emission tomography (PET) with nucleoside analogues is the high background radioactivity in the intestine. We hypothesized that endogenous expression of thymidine kinase in bacterial flora could phosphorylate and trap such radiotracers, contributing to th...

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Bibliographic Details
Main Authors: Alessandro Ruggiero, Peter Brader, Inna Serganova, Pat Zanzonico, Shangde Cai, Neil S. Lipman, Hedvig Hricak, Ronald G. Blasberg
Format: Article
Language:English
Published: SAGE Publications 2010-01-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2010.00006

Internet

https://doi.org/10.2310/7290.2010.00006

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