Innovative synthesis of drug-like molecules using tetrazole as core building blocks

Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules. Typically, tetrazoles are introduced from their nitrile precursors through late-stage functionalization. In this w...

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Bibliographic Details
Main Authors: Jingyao Li, Ajay L. Chandgude, Qiang Zheng, Alexander Dömling
Format: Article
Language:English
Published: Beilstein-Institut 2024-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.20.85