Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming

Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming

The orphan nuclear receptor TLX is a master regulator of postnatal neural stem cell (NSC) self-renewal and neurogenesis; however, it remains unclear how TLX expression is precisely regulated in these tissue-specific stem cells. Here, we show that a highly conserved cis-element within the Tlx locus f...

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Bibliographic Details
Main Authors: Mohammed M. Islam, Derek K. Smith, Wenze Niu, Sanhua Fang, Nida Iqbal, Guoqiang Sun, Yanhong Shi, Chun-Li Zhang
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115002775

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http://www.sciencedirect.com/science/article/pii/S2213671115002775

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