Insights into the biosynthesis of septacidin l-heptosamine moiety unveils a VOC family sugar epimerase

Insights into the biosynthesis of septacidin l-heptosamine moiety unveils a VOC family sugar epimerase

l-Heptopyranoses are important components of bacterial polysaccharides and biological active secondary metabolites like septacidin (SEP), which represents a group of nucleoside antibiotics with antitumor, antifungal, and pain-relief activities. However, little is known about the formation mechanisms...

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Bibliographic Details
Main Authors: Meng Chen, Zhengyan Guo, Jinyuan Sun, Wei Tang, Min Wang, Yue Tang, Pengwei Li, Bian Wu, Yihua Chen
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Natural product
Septacidin
l-heptose
Biosynthesis
Hemiketal
VOC epimerase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522002556

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http://www.sciencedirect.com/science/article/pii/S2211383522002556

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