PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria. In vivo, NETs are induced by bacteria and pro-inflammatory cytokines. We have reported that peptidylargin...

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Bibliographic Details
Main Authors: Marc eLeshner, Shu eWang, Carrie eLewis, Han eZheng, Xiangyun Amy Chen, Lorraine eSanty, Yanming eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Immunology
Subjects:
Histone Modifications
neutrophil extracellular traps
pad4
hypercitrullination
chromatin decondensation
heterochromatin protein 1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00307/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00307/full

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