Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry

Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry

Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-induced gene that catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC), which exerts broad-spectrum antiviral function. To investigate the roles of fish CH25H in Singapore grouper iridovirus (SGIV) and red-spotted grouper ne...

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Bibliographic Details
Main Authors: Ya Zhang, Liqun Wang, Xiaohong Huang, Shaowen Wang, Youhua Huang, Qiwei Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
cholesterol 25-hydroxylase
grouper
Singapore grouper iridovirus
red-spotted grouper nervous necrosis virus
viral replication
interferon-stimulated gene
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00322/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00322/full

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