Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of <i>Herpes Simplex</i> Oncolytic Virus

Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of <i>Herpes Simplex</i> Oncolytic Virus

The dichotomic contribution of cancer cell lysis and tumor immunogenicity is considered essential for effective oncovirotherapy, suggesting that the innate antiviral immune response is a hurdle for efficacy of oncolytic viruses. However, emerging evidence is resizing this view. By sensing cytosolic...

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Bibliographic Details
Main Authors: Guendalina Froechlich, Carmen Caiazza, Chiara Gentile, Anna Morena D’Alise, Maria De Lucia, Francesca Langone, Guido Leoni, Gabriella Cotugno, Vittorio Scisciola, Alfredo Nicosia, Elisa Scarselli, Massimo Mallardo, Emanuele Sasso, Nicola Zambrano
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
<i>Herpes simplex</i>
HSV-1
oncolytic virus
immunogenic cell death
STING knockout
RNA profiling
Online Access:https://www.mdpi.com/2072-6694/12/11/3407

Internet

https://www.mdpi.com/2072-6694/12/11/3407

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