Pharmacogenetics and Adverse Events in the Use of Fluoropyrimidine in a Cohort of Cancer Patients on Standard of Care Treatment in Zimbabwe

Pharmacogenetics and Adverse Events in the Use of Fluoropyrimidine in a Cohort of Cancer Patients on Standard of Care Treatment in Zimbabwe

Fluoropyrimidines are commonly used in the treatment of colorectal cancer. They are, however, associated with adverse events (AEs), of which gastrointestinal, myelosuppression and palmar-plantar erythrodysesthesia are the most common. Clinical guidelines are used for fluoropyrimidine dosing based on...

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Bibliographic Details
Main Authors: Boluwatife Lawrence Afolabi, Tinashe Mazhindu, Chikwambi Zedias, Margaret Borok, Ntokozo Ndlovu, Collen Masimirembwa, on behalf of Consortium for Genomics and Therapeutics in Africa (CGTA)
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Journal of Personalized Medicine
Subjects:
adverse drug reactions
genetic polymorphism
cancer
capecitabine
fluorouracil
precision medicine
Online Access:https://www.mdpi.com/2075-4426/13/4/588

Internet

https://www.mdpi.com/2075-4426/13/4/588

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