Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice

Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice

Postnatal critical periods of synaptic plasticity (CPsp) are characterized by profound neural network refinement, which is shaped by synaptic activity and sculpted by maturation of the GABAergic network. Even after therapeutic hypothermia (TH), neonatal hypoxia-ischemia (HI) impairs two triggers for...

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Bibliographic Details
Main Authors: Pritika Parmar, Harisa Spahic, Charles Lechner, Mark St. Pierre, Katherine Carlin, Michael Nugent, Raul Chavez-Valdez
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Neurobiology of Disease
Subjects:
CA1
Interneurons
Memory
Parvalbumin
Neonatal hypoxia-ischemia
hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003243

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http://www.sciencedirect.com/science/article/pii/S0969996124003243

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