Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

Glymphatic transport, defined as cerebrospinal fluid (CSF) peri-arterial inflow into brain, and interstitial fluid (ISF) clearance, is reduced in the aging brain. However, it is unclear whether glymphatic transport affects the distribution of soluble Aβ in Alzheimer's disease (AD). In wild type...

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Bibliographic Details
Main Authors: Weiguo Peng, Thiyagarajan M. Achariyar, Baoman Li, Yonghong Liao, Humberto Mestre, Emi Hitomi, Sean Regan, Tristan Kasper, Sisi Peng, Fengfei Ding, Helene Benveniste, Maiken Nedergaard, Rashid Deane
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neurobiology of Disease
Subjects:
Convective ISF flow
Astrocytes
AQP4
CSF
Brain ISF clearance
Lymphatic system
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301097

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http://www.sciencedirect.com/science/article/pii/S0969996116301097

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