Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells

Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells

The Wnt/β-catenin pathway plays a crucial role in development and renewal of the intestinal epithelium. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), a rate-limiting ketogenic enzyme in the synthesis of ketone body β-hydroxybutyrate (βHB), contributes t...

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Bibliographic Details
Main Authors: Ji Tae Kim, Chang Li, Heidi L. Weiss, Yuning Zhou, Chunming Liu, Qingding Wang, B. Mark Evers
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
ketogenesis
HMGCS2
Wnt/β-catenin pathway
PPARγ
intestinal cells
β-hydroxybutyrate
Online Access:https://www.mdpi.com/2073-4409/8/9/1106

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https://www.mdpi.com/2073-4409/8/9/1106

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