Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population

Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population

Integrin regulation by Rap1 is indispensable for lymphocyte recirculation. In mice having B-cell-specific Rap1a/b double knockouts (DKO), the number of B cells in lymph nodes decreased to approximately 4% of that of control mice, and B cells were present in the spleen and blood. Upon the immunizatio...

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Bibliographic Details
Main Authors: Sayaka Ishihara, Tsuyoshi Sato, Risa Sugioka, Ryota Miwa, Haruka Saito, Ryota Sato, Hidehiro Fukuyama, Akihiko Nakajima, Satoshi Sawai, Ai Kotani, Koko Katagiri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
B cells
Rap1
germinal center
B-1a
chemotactic factor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.624419/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.624419/full

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