Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity
Glial engulfment declines with age, but the mechanism is unclear. Here authors show that in the Drosophilaolfactory system, glial phagocytosis of injury-induced degenerating axons decreases with age due to reduced PI3K/Draper activity, and restoring Draper in aged glia rescues such defects.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12871 |