PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties

PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties

A new PSMA ligand (PSMA-D4) containing the Glu-CO-Lys pharmacophore connected with a new linker system (L-Trp-4-Amc) and chelator DOTA was developed for radiolabeling with therapeutic radionuclides. Herein we describe the synthesis, radiolabeling, and preliminary biological evaluation of the novel P...

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Bibliographic Details
Main Authors: Piotr Garnuszek, Urszula Karczmarczyk, Michał Maurin, Arkadiusz Sikora, Jolanta Zaborniak, Justyna Pijarowska-Kruszyna, Antoni Jaroń, Monika Wyczółkowska, Wioletta Wojdowska, Dariusz Pawlak, Piotr F. J. Lipiński, Renata Mikołajczak
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
PSMA
DOTA conjugated PSMA ligand (PSMA-D4)
prostate cancer
lutetium-177
yttrium-90
scandium-47
Online Access:https://www.mdpi.com/1422-0067/22/5/2731

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https://www.mdpi.com/1422-0067/22/5/2731

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