Comparative Serum Analyses Identify Cytokines and Hormones Commonly Dysregulated as Well as Implicated in Promoting Osteolysis in MMP-2-Deficient Mice and Children

Comparative Serum Analyses Identify Cytokines and Hormones Commonly Dysregulated as Well as Implicated in Promoting Osteolysis in MMP-2-Deficient Mice and Children

Deficiency of matrix metalloproteinase 2 (MMP-2) causes a complex syndrome characterized by multicentric osteolysis, nodulosis, and arthropathy (MONA) as well as cardiac valve defects, dwarfism and hirsutism. MMP-2 deficient (Mmp2–/–) mice are a model for this rare multisystem pediatric syndrome but...

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Bibliographic Details
Main Authors: Hassan Sarker, Eugenio Hardy, Ayman Haimour, Mahmoud A. Karim, Sabine Scholl-Bürgi, John A. Martignetti, Lorenzo D. Botto, Carlos Fernandez-Patron
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
matrix metalloproteinase
multicentric osteolysis nodulosis and arthropathy
matrix metalloproteinase-2
cytokines
cortisol
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.568718/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.568718/full

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