Evaluation of Cross-Immunity to the Mpox Virus Due to Historic Smallpox Vaccination

Evaluation of Cross-Immunity to the Mpox Virus Due to Historic Smallpox Vaccination

When the Mpox virus (MPXV) began spreading globally in 2022, it became critical to evaluate whether residual immunity from smallpox vaccination provided cross-protection. To assess the cross-immune response to MPXV, we collected serum samples (<i>n</i> = 97) and PBMCs (<i>n</i&g...

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Bibliographic Details
Main Authors: Giulia Matusali, Elisa Petruccioli, Eleonora Cimini, Francesca Colavita, Aurora Bettini, Eleonora Tartaglia, Settimia Sbarra, Silvia Meschi, Daniele Lapa, Massimo Francalancia, Licia Bordi, Valentina Mazzotta, Sabrina Coen, Klizia Mizzoni, Alessia Beccacece, Emanuele Nicastri, Luca Pierelli, Andrea Antinori, Enrico Girardi, Francesco Vaia, Alessandro Sette, Alba Grifoni, Delia Goletti, Vincenzo Puro, Fabrizio Maggi
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Vaccines
Subjects:
Mpox virus
Orthopoxvirus
smallpox-vaccine
adaptive immunity
neutralizing antibodies
T cell response
Online Access:https://www.mdpi.com/2076-393X/11/10/1541

Internet

https://www.mdpi.com/2076-393X/11/10/1541

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