Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

Abstract In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid β-oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic reticulum Ca2+α ATPase (SERCA) expression is downregulated and mitochondrial function is reduced in HF, perhaps par...

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Bibliographic Details
Main Authors: Zhiwei Dong, Pei Zhao, Ming Xu, Chen Zhang, Wei Guo, Huihua Chen, Jing Tian, Hongchang Wei, Rong lu, Tongtong Cao
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02360-5

Internet

https://doi.org/10.1038/s41598-017-02360-5

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