Comprehensive Modeling of Spinal Muscular Atrophy in Drosophila melanogaster

Comprehensive Modeling of Spinal Muscular Atrophy in Drosophila melanogaster

Spinal muscular atrophy (SMA) is a neurodegenerative disorder that affects motor neurons, primarily in young children. SMA is caused by mutations in the Survival Motor Neuron 1 (SMN1) gene. SMN functions in the assembly of spliceosomal RNPs and is well conserved in many model systems including mouse...

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Bibliographic Details
Main Authors: Ashlyn M. Spring, Amanda C. Raimer, Christine D. Hamilton, Michela J. Schillinger, A. Gregory Matera
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SMN1
SMN2
spinal muscular atrophy
SMA
invertebrate models
neuromuscular disease
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00113/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00113/full

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