Cancer‐associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T‐cell suppression

Cancer‐associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T‐cell suppression

In some tumors, a small number of cancer cells are scattered in a large fibrotic stroma. Here, we demonstrate a novel mechanism for expansion of pro‐tumor fibroblasts via cancer‐associated fibroblast (CAF)‐mediated education of normal fibroblasts (NFs). When NFs were incubated with conditioned mediu...

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Bibliographic Details
Main Authors: Go Itoh, Kurara Takagane, Yuma Fukushi, Sei Kuriyama, Michinobu Umakoshi, Akiteru Goto, Kazuyoshi Yanagihara, Masakazu Yashiro, Masamitsu Tanaka
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Molecular Oncology
Subjects:
asporin
CAF‐educated fibroblasts
CD8+ T cells
IGF‐I
kynurenine
Online Access:https://doi.org/10.1002/1878-0261.13077

Internet

https://doi.org/10.1002/1878-0261.13077

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