Cancer‐associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T‐cell suppression
In some tumors, a small number of cancer cells are scattered in a large fibrotic stroma. Here, we demonstrate a novel mechanism for expansion of pro‐tumor fibroblasts via cancer‐associated fibroblast (CAF)‐mediated education of normal fibroblasts (NFs). When NFs were incubated with conditioned mediu...
Main Authors: | Go Itoh, Kurara Takagane, Yuma Fukushi, Sei Kuriyama, Michinobu Umakoshi, Akiteru Goto, Kazuyoshi Yanagihara, Masakazu Yashiro, Masamitsu Tanaka |
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Format: | Article |
Language: | English |
Published: |
Wiley
2022-01-01
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Series: | Molecular Oncology |
Subjects: | |
Online Access: | https://doi.org/10.1002/1878-0261.13077 |
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