Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley Rats
The effect of consuming breads made with wheat flour and Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) wholemeal flour on Sprague Dawley rats with hyperlipidaemia and hyperglycaemia induced through feeding was studied. Four diets were provided: control (CD: Ratarina<sup>®<...
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MDPI AG
2020-06-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/9/6/707 |
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| author | Adriana Beatriz Sánchez-Urdaneta Keyla Carolina Montero-Quintero Pedro González-Redondo Edgar Molina Belkys Bracho-Bravo Rafael Moreno-Rojas |
| author_facet | Adriana Beatriz Sánchez-Urdaneta Keyla Carolina Montero-Quintero Pedro González-Redondo Edgar Molina Belkys Bracho-Bravo Rafael Moreno-Rojas |
| author_sort | Adriana Beatriz Sánchez-Urdaneta |
| collection | DOAJ |
| description | The effect of consuming breads made with wheat flour and Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) wholemeal flour on Sprague Dawley rats with hyperlipidaemia and hyperglycaemia induced through feeding was studied. Four diets were provided: control (CD: Ratarina<sup>®</sup>), commercial bread (CBD), bread with 100 g·kg<sup>−1</sup> (ABD10) and 200 g·kg<sup>−1</sup> (ABD20) amaranth flour. Zoometric and blood chemistry parameters were measured before and after consuming the diets. A completely random factorial design of 2 × 4 × 2 was used. The factors were blood lipids and glucose level (normal, N and elevated, E), diet (CD, CBD, ABD10 and ABD20) and sex (female, F and male, M). The rats consuming ABD10 and ABD20 diets presented the lowest glucose values, although with no differences (<i>p</i> > 0.05) between the groups of elevated blood lipids and glucose rats (E). Triglyceride concentrations decreased in ABD10 and ABD20 treatments in comparison with CD, elevated blood lipids and glucose (E) rats, while ABD10 rats showed lower total cholesterol level than normal (N) rats. The high-density lipoprotein cholesterol values increased in the ABD10 and ABD20 groups (<i>p</i> < 0.05), while it did lower for very low-density lipoprotein cholesterol and cardiac risk index (<i>p</i> < 0.05). In ABD10 and ABD20 treatments, the abdominal circumference decreased in both sexes (<i>p</i> < 0.05) between weeks 23 and 31. In conclusion, consumption of bread with amaranth improved lipid profiles of rats and could help to prevent metabolic and cardiovascular diseases. |
| first_indexed | 2024-03-10T19:27:16Z |
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| id | doaj.art-f6c7f5b5ea174baba105b4fa311800f3 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T19:27:16Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-f6c7f5b5ea174baba105b4fa311800f32023-11-20T02:27:57ZengMDPI AGFoods2304-81582020-06-019670710.3390/foods9060707Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley RatsAdriana Beatriz Sánchez-Urdaneta0Keyla Carolina Montero-Quintero1Pedro González-Redondo2Edgar Molina3Belkys Bracho-Bravo4Rafael Moreno-Rojas5Departamento de Botánica, Facultad de Agronomía, Universidad del Zulia, Maracaibo 4001, VenezuelaDepartamento de Química, Facultad de Humanidades y Educación, Universidad del Zulia, Maracaibo 4001, VenezuelaDepartamento de Ciencias Agroforestales, Escuela Técnica Superior de Ingeniería Agronómica, Universidad de Sevilla, 41013 Sevilla, SpainDepartamento de Química, Facultad de Humanidades y Educación, Universidad del Zulia, Maracaibo 4001, VenezuelaDepartamento de Estadística, Facultad de Agronomía, Universidad del Zulia, Maracaibo 4001, VenezuelaDepartamento de Bromatología y Tecnología de los Alimentos, Universidad de Córdoba, 14071 Córdoba, SpainThe effect of consuming breads made with wheat flour and Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) wholemeal flour on Sprague Dawley rats with hyperlipidaemia and hyperglycaemia induced through feeding was studied. Four diets were provided: control (CD: Ratarina<sup>®</sup>), commercial bread (CBD), bread with 100 g·kg<sup>−1</sup> (ABD10) and 200 g·kg<sup>−1</sup> (ABD20) amaranth flour. Zoometric and blood chemistry parameters were measured before and after consuming the diets. A completely random factorial design of 2 × 4 × 2 was used. The factors were blood lipids and glucose level (normal, N and elevated, E), diet (CD, CBD, ABD10 and ABD20) and sex (female, F and male, M). The rats consuming ABD10 and ABD20 diets presented the lowest glucose values, although with no differences (<i>p</i> > 0.05) between the groups of elevated blood lipids and glucose rats (E). Triglyceride concentrations decreased in ABD10 and ABD20 treatments in comparison with CD, elevated blood lipids and glucose (E) rats, while ABD10 rats showed lower total cholesterol level than normal (N) rats. The high-density lipoprotein cholesterol values increased in the ABD10 and ABD20 groups (<i>p</i> < 0.05), while it did lower for very low-density lipoprotein cholesterol and cardiac risk index (<i>p</i> < 0.05). In ABD10 and ABD20 treatments, the abdominal circumference decreased in both sexes (<i>p</i> < 0.05) between weeks 23 and 31. In conclusion, consumption of bread with amaranth improved lipid profiles of rats and could help to prevent metabolic and cardiovascular diseases.https://www.mdpi.com/2304-8158/9/6/707<i>Amaranthus dubius</i>breadhyperlipidaemiahypoglycaemiapseudocerealrat |
| spellingShingle | Adriana Beatriz Sánchez-Urdaneta Keyla Carolina Montero-Quintero Pedro González-Redondo Edgar Molina Belkys Bracho-Bravo Rafael Moreno-Rojas Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley Rats Foods <i>Amaranthus dubius</i> bread hyperlipidaemia hypoglycaemia pseudocereal rat |
| title | Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley Rats |
| title_full | Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley Rats |
| title_fullStr | Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley Rats |
| title_full_unstemmed | Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley Rats |
| title_short | Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (<i>Amaranthus dubius</i> Mart. ex Thell.) on Sprague Dawley Rats |
| title_sort | hypolipidemic and hypoglycaemic effect of wholemeal bread with amaranth i amaranthus dubius i mart ex thell on sprague dawley rats |
| topic | <i>Amaranthus dubius</i> bread hyperlipidaemia hypoglycaemia pseudocereal rat |
| url | https://www.mdpi.com/2304-8158/9/6/707 |
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