Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7). Transfer of antibodies against COL7 into mice results in a subepidermal blistering phenotype, strictly depending on the compl...

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Bibliographic Details
Main Authors: Sidonia Mihai, Misa Hirose, Yi Wang, Joshua M. Thurman, V. Michael Holers, B. Paul Morgan, Jörg Köhl, Detlef Zillikens, Ralf J. Ludwig, Falk Nimmerjahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
autoantibodies
complement
complement inhibition
immunotherapy
autoimmune diseases
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00535/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00535/full

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