Familial Hypertrophic Cardiomyopathy: Functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development

Familial Hypertrophic Cardiomyopathy: Functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development

Familial hypertrophic cardiomyopathy (FHC) is the most frequent inherited cardiac disease. It has been related to numerous mutations in many sarcomeric and even some non-sarcomeric proteins. So far, however, no common mechanism has been identified by which the many different mutations in different s...

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Bibliographic Details
Main Authors: Bernhard eBrenner, Benjamin eSeebohm, Snigdha eTripathi, Judith eMontag, Theresia eKraft
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Physiology
Subjects:
Allelic Imbalance
MYH7-mutations
myocyte disarray
interstitial fibrosis
converter domain of myosin head
myosin head stiffness
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00392/full

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http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00392/full

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