Mitochondria-Targeted Antioxidant SkQ1 Prevents the Development of Experimental Colitis in Mice and Impairment of the Barrier Function of the Intestinal Epithelium

Mitochondria-Targeted Antioxidant SkQ1 Prevents the Development of Experimental Colitis in Mice and Impairment of the Barrier Function of the Intestinal Epithelium

Mitochondria-targeted antioxidants have become promising candidates for the therapy of various pathologies. The mitochondria-targeted antioxidant SkQ1, which is a derivative of plastoquinone, has been successfully used in preclinical studies for the treatment of cardiovascular and renal diseases, an...

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Bibliographic Details
Main Authors: Artem V. Fedorov, Maria A. Chelombitko, Daniil A. Chernyavskij, Ivan I. Galkin, Olga Yu. Pletjushkina, Tamara V. Vasilieva, Roman A. Zinovkin, Boris V. Chernyak
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
dextran sulfate sodium
SkQ1
Caco-2
intestinal epithelium
ulcerative colitis
reactive oxygen species
Online Access:https://www.mdpi.com/2073-4409/11/21/3441

Internet

https://www.mdpi.com/2073-4409/11/21/3441

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