Double-Negative T Cells Regulate Hepatic Stellate Cell Activation to Promote Liver Fibrosis Progression via NLRP3

Double-Negative T Cells Regulate Hepatic Stellate Cell Activation to Promote Liver Fibrosis Progression via NLRP3

AimWe mainly explored the role and mechanism of double-negative T cells (DNTs) in liver fibrosis.MethodsDNTs were co-cultured with mouse hepatic stellate cells (HSCs). Later, cell viability was detected by Cell Counting Kit-8 (CCK-8) assay; α-SMA expression was measured through fluorescence staining...

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Bibliographic Details
Main Authors: Yi Yang, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Caiqun Zhang, Li Guo, Chenyang Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
double-negative T cells
liver fibrosis
NLRP3
TNFR1
hepatic stellate cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.857116/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.857116/full

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