Lipid Modulation in the Formation of β-Sheet Structures. Implications for De Novo Design of Human Islet Amyloid Polypeptide and the Impact on β-Cell Homeostasis

Lipid Modulation in the Formation of β-Sheet Structures. Implications for De Novo Design of Human Islet Amyloid Polypeptide and the Impact on β-Cell Homeostasis

Human islet amyloid polypeptide (hIAPP) corresponds to a 37-residue hormone present in insulin granules that maintains a high propensity to form β-sheet structures during co-secretion with insulin. Previously, employing a biomimetic approach, we proposed a panel of optimized IAPP sequences with only...

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Bibliographic Details
Main Authors: Israel Martínez-Navarro, Raúl Díaz-Molina, Angel Pulido-Capiz, Jaime Mas-Oliva, Ismael Luna-Reyes, Eustolia Rodríguez-Velázquez, Ignacio A. Rivero, Marco A. Ramos-Ibarra, Manuel Alatorre-Meda, Victor García-González
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Biomolecules
Subjects:
hIAPP
amyloidogenesis
insulin granules
endoplasmic reticulum
anionic lipids
F<sub>23</sub>R variant
Online Access:https://www.mdpi.com/2218-273X/10/9/1201

Internet

https://www.mdpi.com/2218-273X/10/9/1201

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