Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives

Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives

Abstract In this study, 5-amino-nicotinic acid derivatives (1–13) have been designed and synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase enzymes. The synthesized compounds (1–13) exhibited promising α-amylase and α-glucosidase activities. IC50 values for α-amyl...

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Bibliographic Details
Main Authors: Muhammad Nawaz, Muhammad Taha, Faiza Qureshi, Nisar Ullah, Manikandan Selvaraj, Sumaira Shahzad, Sridevi Chigurupati, Abdul Waheed, Fadiah Ammar Almutairi
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Chemistry
Subjects:
5-Amino-nicotinic acid
Spectral studies
NMR
HR-MS
FTIR
α-Amylase activity
Online Access:http://link.springer.com/article/10.1186/s13065-020-00695-1

Internet

http://link.springer.com/article/10.1186/s13065-020-00695-1

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