Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells

Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells

Abstract Background Metabolic disorders are associated with increased incidence, aggressive phenotype and poor outcome of breast cancer (BC) patients. For instance, hyperinsulinemia is an independent risk factor for BC and the insulin/insulin receptor (IR) axis is involved in BC growth and metastasi...

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Bibliographic Details
Main Authors: Domenica Scordamaglia, Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Damiano Cosimo Rigiracciolo, Lucia Muglia, Azzurra Zicarelli, Salvatore De Rosis, Francesca Giordano, Anna Maria Miglietta, Ernestina Marianna De Francesco, Veronica Vella, Antonino Belfiore, Rosamaria Lappano, Marcello Maggiolini
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Translational Medicine
Subjects:
Metformin
Insulin
Insulin receptor
Breast cancer
BCAHC-1 cells
Online Access:https://doi.org/10.1186/s12967-022-03463-y

Internet

https://doi.org/10.1186/s12967-022-03463-y

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