STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition

STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition

Abstract Stromal antigen 2 (STAG2), a subunit of the cohesin complex, is recurrently mutated in various tumors. However, the role of STAG2 in DNA repair and its therapeutic implications are largely unknown. Here it is reported that knockout of STAG2 results in increased double‐stranded breaks (DSBs)...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Jie Zhou, Run‐Cong Nie, Zhang‐Ping He, Xiao‐Xia Cai, Jie‐Wei Chen, Wen‐ping Lin, Yi‐Xin Yin, Zhi‐Cheng Xiang, Tian‐Chen Zhu, Juan‐Juan Xie, You‐Cheng Zhang, Xin Wang, Peng Lin, Dan Xie, Alan D D'Andrea, Mu‐Yan Cai
Format: Artikel
Sprache:English
Veröffentlicht: Wiley 2023-12-01
Schriftenreihe:Advanced Science
Schlagworte:
ATM inhibitors
homologous recombination
PARP inhibitors
STAG2
synthetic lethality
Online Zugang:https://doi.org/10.1002/advs.202302494

Online

https://doi.org/10.1002/advs.202302494

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