Critical role of Rho proteins in myosin light chain di-phosphorylation during early phase of endothelial barrier disruption

Abstract We previously reported the Rho-associated coiled-coil containing protein kinase (ROCK)-mediated di-phosphorylation of myosin light chain (MLC) and actin bundle formation at the cell periphery as early events of the endothelial barrier disruption. We herein examined the role of RhoA during e...

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Bibliographic Details
Main Authors: Mayumi Hirano, Katsuya Hirano
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Physiological Sciences
Subjects:
Online Access:https://doi.org/10.1186/s12576-022-00857-x