De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report

De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report

The transformation to SCLC is a known mechanism of resistance against molecularly targeted therapies. This study reports a patient with untreated lung adenocarcinoma, characterized by a KRAS G12C mutation, which transformed into SCLC before treatment. Both the adenocarcinoma and SCLC components were...

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Bibliographic Details
Main Authors: Takanori Ito, MD, Issei Oi, MD, PhD, Zentaro Saito, MD, Takuma Imakita, MD, Osamu Kanai, MD, Kohei Fujita, MD, PhD, Hiromasa Tachibana, MD, Koki Moriyoshi, MD, PhD, Tadashi Mio, MD, PhD
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:JTO Clinical and Research Reports
Subjects:
KRAS G12C
Transformation
Small cell lung cancer (SCLC)
Sotorasib
Case report
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364323000498

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http://www.sciencedirect.com/science/article/pii/S2666364323000498

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