Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts

Disruption of extracellular matrix (ECM) homeostasis and subchondral bone remodeling play significant roles in osteoarthritis (OA) pathogenesis. Vindoline (Vin), an indole alkaloid extracted from the medicinal plant Catharanthus roseus, possesses anti-inflammatory properties. According to previous s...

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Bibliographic Details
Main Authors: Meisong Zhu, Qiang Xu, Xinmin Yang, Haibo Zhan, Bin Zhang, Xuqiang Liu, Min Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
vindoline
osteoarthritis
extracellular matrix
osteoclastogenesis
NF-κB pathway
ERK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.764598/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.764598/full

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