Variants in CPT1A, FADS1, and FADS2 are associated with higher levels of estimated plasma and erythrocyte delta 5 desaturases in Alaskan Eskimos

Variants in CPT1A, FADS1, and FADS2 are associated with higher levels of estimated plasma and erythrocyte delta 5 desaturases in Alaskan Eskimos

The delta-5 and delta-6 desaturases (D5D and D6D), encoded by fatty acid desaturase 1 (FADS1) and 2 (FADS2) genes, respectively, are rate-limiting enzymes in the metabolism of ω-3 and ω-6 fatty acids. The objective of this study was to identify genes influencing variation in estimated D5D and D6D ac...

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Bibliographic Details
Main Authors: V. Saroja eVoruganti, Paul B Higgins, Sven OE Ebbesson, John ekennish, Harald HH Goring, Karin eHaack, Sandra eLaston, Eugene eDrigalenko, Charlotte R Wenger, William eHarris, Richard R Fabsitz, Richard B Devereux, Jean eMacCluer, Joanne eCurran, Melanie eCarless, Matthew eJohnson, Eric eMoses, John eBlangero, Jason G Umans, Barbara V Howard, Shelley eCole, Anthony Gean Comuzzie
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Genetics
Subjects:
Essential fatty acids
Single nucleotide polymorphisms
Bayesian quantitative trait nucleotide analysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00086/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00086/full

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