Quantifying the Effects of Combination Trastuzumab and Radiation Therapy in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Background: Trastuzumab induces cell cycle arrest in HER2-overexpressing cells and demonstrates potential in radiosensitizing cancer cells. The purpose of this study is to quantify combination trastuzumab and radiotherapy to determine their synergy. Methods: In vitro, HER2+ cancer cells were treated...

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Bibliographic Details
Main Authors: Meghan J. Bloom, Patrick N. Song, John Virostko, Thomas E. Yankeelov, Anna G. Sorace
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/14/17/4234